Pyrazinamide Púdar

Cad é É Pyrazinamide In Tb Cóireáil

Pyrazinamide púdar is a drug primarily used to treat tuberculosis (TB). It is a crystalline powder that is white or off-white in color, somewhat soluble in water, and only sporadically soluble in ethanol or methanol. This product only kills Mycobacterium tuberculosis and has no antibacterial activity against other bacteria. The strength of its anti-tuberculosis effect is closely related to the PH of the environment. When PH=5~5.5, the antibacterial activity is most vigorous; when PH=7, the antibacterial effect is significantly weakened; animal experiments have confirmed that this product can enter cells and has a significant synergistic effect when combined with isoniazid. It is also effective against extracellular tuberculosis bacteria in an acidic environment. There is no cross-resistance between this product and other anti-tuberculosis drugs, and it is easy to develop drug resistance when used alone. The mechanism of action may be that PZA penetrates macrophages containing Mycobacterium tuberculosis and is converted into pyrazinoic acid to exert its antibacterial effect. Depending on the drug concentration and bacterial sensitivity, this product is a nicotinamide derivative with bacteriostatic or bactericidal effects. This product only has antibacterial activity when the PH is acidic.

Is é an struchtúr de seo táirge cosúil le nicotinamide % 2c agus sé is féidir a bactericidal éifeacht nuair a théann sé cealla . Faoi íseal PH coinníollacha % 2c an antibacterial gníomhaíocht is dian . seo táirge is a chéad líne frith-eitinn drugaí gan tras-fhriotaíocht le eile frith-eitinn drugaí. Tá sé den chuid is mó a úsáidtear le haghaidh cásanna in cé acu an chéad líne drugaí cóireáil neamhéifeachtach. Seo táirge is féidir go tapa a fhorbairt drugaí friotaíocht nuair a úsáidtear ina n-aonar agus riachtanais le a a úsáid i teaglaim eile frith-eitinn drugaí.

They are combined with other anti-tuberculosis drugs for tuberculosis that have failed to respond to first-line anti-tuberculosis drugs (such as streptomycin, isoniazid, rifampicin, and ethambutol). This product is only effective against mycobacteria. In the past, this product was used as a second-line drug and was often used for retreatment of patients who failed other anti-tuberculosis drugs. Many clinical studies have shown that the short-course treatment plan containing this product is suitable for the initial treatment of phlegm bacteria-positive cases and is generally used for 2 to 3 months. This plan can significantly reduce the re-positive rate of phlegm bacteria after the treatment. This product has been recognized as one of the components of triple or quadruple regimens in short-course chemotherapy.

Más ní mór duit PZA púdar % 2c Xi% 27an Sonwu is féidir soláthar pyrazinamide . Ag breathnú ar aghaidh go éisteacht ó tú.

Teastas As Anailís

Cá háit Go Ceannaigh Pyrazinamide

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection begins from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So lorg le haghaidh Xi% 27an Sonwu Biotech Co. Ltd . nuair ceannach PZA Púdar.

Xi'an Sonwu ensures product quality so samples can be supplied. Here is the quantity.

Custaiméirí% 27 Go maith Comment

Cad é Is Pyrazinamide Úsáidte Le haghaidh

Tá sé go príomha úsáidtear le haghaidh an cóireáil de eitinn (TB) . Tá sé an riachtanach comhpháirt de an caighdeán regimens an Domhanda Sláinte Eagraíocht (WHO) molta le haghaidh drugaí-íogair agus drugaí-resistant TB.

Nuair comhcheangailte le eile frith-TB míochainí% 2c den sórt sin mar isoniazid% 2c rifampicin% 2c agus ethambutol% 2c cuidíonn sé cóireáil gníomhach TB ionfhabhtuithe go héifeachtach . Tá sé go háirithe éifeachtach i marú díomhaoin nó mall ag fás baictéir go minic i láthair in TB loit.

Tá sé freisin uaireanta a úsáidtear mar a coisctheach teiripe do daoine aonair a bhí le déanaí nochtadh go TB nó a a folaigh TB ionfhabhtú ach nach bhfuil fós forbartha an gníomhach galar . Seo coisctheach cóireáil is féidir cabhrú laghdú an riosca de folaigh TB dul chun cinn go gníomhach TB.

Cad Aicme As Antaibheathaigh Is Pyrazinamide

Tá sé ní aicmithe mar an antaibheathach . Tá sé aicmithe mar an antimycobacterial gníomhaire a úsáidtear go sainráite le haghaidh cóireáil eitinn (TB) . Cé go bhfuil go leor antaibheathaigh is féidir go héifeachtach cóireáil baictéar ionfhabhtuithe % 2c / CZA is go príomha úsáidtear i gcoinne Mycobacterium eitinn % 2c na baictéir 2c freagrach as cúis TB TB iad seo baictéir % 27s fás agus meitibileacht% 2c cabhrú an ionfhabhtú % 27s baint.

Pyrazinamide Meicníocht As Gníomh

Pyrazinamide púdar's exact mechanism of action is not fully understood, but several theories have been proposed. Here are a few possible ways in which PZA may exert its effects:

1. Comhshó go pyrazinoic acid (POA): It is converted to its active form, pyrazinoic acid, by the einsím pyrazinamidase. Tarlaíonn sé seo comhshó intracellularly in Mycobacterium eitinn . POA is thought to disrupt an baictéar % 27s membrane poitéinseal agus aigéadú próisis % 2c cosc a fás agus marthanais.

2. Cur isteach de sailleach aigéad meitibileacht: D'fhéadfadh sé cur isteach le sailleacha aigéad sintéis agus úsáid laistigh the bacterial cell. An cur isteach féadfaidh result in the exhaustion of energy reserves, impeding the bacterium's capacity to increase and endure.

3. PH-dependent action: It acts preferentially in an acidic environment, such as found within the phagolysosome of macrophages where M. tuberculosis resides. It is believed that PZA is most effective in this acidic environment, possibly through the protonation of its active form, POA.

4. Synergistic effect: Pyrazinam de has synergized with anti-TB drugs like rifampicin and isoniazid. An teaglaim de these drugs enhances their overall efficacy against M. tuberculosis.

It's crucial to remember that the precise method through which functions may entail a mix of these elements and may differd based on the particulars and setting of the illness. Further research is still needed to elucidate the complete mechanism of action of PZA fully.

Cad iad An Taobh Éifeachtaí As Pyrazinamide

PZA% 2c cosúil le aon cógas % 2c is féidir cúis taobh éifeachtaí . An is mó coitianta taobh éifeachtaí san áireamh% 3a

1. Gastrointestinal suaitheadh: Nausea, urlacan, agus caillteanas de appetite are commonly reported side effects. Ag tabhairt é le bia is féidir cabhrú laghdú na comharthaí seo.

2. Hyperuricemia: It can increase uric acid levels in the blood, which may lead to gout or worsen pre-existing gout symptoms. Daoine aonair le a history of gout should be closely monitored during treatment.

3. Joint pain: Some individuals may experience joint pain or arthritis-like symptoms during it therapy. Tá sé seo taobh éifeacht de ghnáth inchúlaithe ar scor de an cógas.

4. Craiceann frithghníomhartha: Craiceann rashes agus itching a bheith tuairiscithe in roinnt cásanna. Ba chóir a gríos nó eile tásca de an frithghníomh ailléirgeach le feiceáil, such as hives or difficulty breathing, seek medical attention láithreach.

5. Hepatotoxicity% 3a Tá sé an poitéinseal chun cúis ae damáiste. Comharthaí ae tocsaineacht d'fhéadfadh san áireamh buí de an craiceann nó súile (jaundice) % 2c dorcha fual % 2c bhoilg pian % 2c nó unexplained tuirse . Rialta monatóireacht de ae feidhm is ríthábhachtach le linn cóireála.

6. Lárnach neirbhíseach córas éifeachtaí: Annamh, it can cause neurological side effects, including confusion, meadhrán, or hallucinations. If you experience any unusual neurological symptoms, consult your healthcare provider.

Conas Go leor Mg As Pyrazinamide Ba chóir I Tóg

An is gnách dosage do daoine fásta % 2c comhcheangailte le eile frith-eitinn drugaí % 2c is 5 go 8.75 mg% 2fkg de comhlacht meáchan gach 6 uair an chloig % 2c 6 / 6 6 go 11.7 mg% 2fkg gach 8 uair an chloig % 2c suas go 3g in aghaidh an lae . Nuair a cóireáil isoniazid-resistant baictéar ionfhabhtuithe , sé is féidir a mhéadú go dtí 60 mg% 2fkg laethúil . Leanaí níor chóir úsáid i i mura gá . Nuair a iarratas a dhéanamh iad , one ba chóir go cúramach smaoineamh na sochair agus míbhuntáistí .

① It can also be administered intermittently, 50 mg/kg twice a week. ② When it is used alone to treat tuberculosis, bacteria are prone to develop drug resistance, so it is often used in combination with other anti-tuberculosis drugs. The course of treatment may last 1-2 years, even several years, or indefinitely. ③It is usually not suit for patients with ae mífheidhmiú mura gá . Daoine le laghdaithe duánach feidhm ná ní gá a laghdú an dáileog nuair ag baint úsáide as é . Daoine Fásta 30 go 35 mg kg in a singil béile in aghaidh an lae in aghaidh an lae . dóibh siúd iad siúd meá níos mó ná 50 kg % 2c 2 g in aghaidh an lae % 3b dóibh siúd ag meá thar 75 kg % 2c 2.5 g in aghaidh an lae . Do leanaí , 7b % 7b 13% 7d% 7d mg% 2fkg in aghaidh an lae.

Ach choigeartú do do dosage tar éis dul i gcomhairle do dochtúir.

Monarcha

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced t sting equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

Teastas

Pacáil

Loighistic Nuashonrú

I suimiú le ráthaíocht táirge quality% 2c an eile an chuid is mó ríthábhachtach rud is go cliaint faigheann na earraí go réidh . So% 2c Xi% 27an Sonwu soláthairtí gach cineál de cúiréirí de réir le éagsúla riachtanais.

Ceisteanna Coitianta

1. Conas go fiosrú?

Is féidir linn a bheith bainte amach ag fón % 2c ríomhphost % 2c nó sóisialta meáin.

2. Conas a dhéanann tú ráthaíocht an cáilíocht de táirgí % 3f

Gach baisc riachtanais le a a bheith tástáil agus is féidir soláthar COA do custaiméirí . Ina theannta sin% 2c gach na táirgí pas an tástáil % 3a HPLC% 2c UV% 2c GC% 2c TLC % 2c etc . Táimid comhoibriú le tríú páirtithe chomh maith le 2c like SGS.

3. Conas do tú pacáiste agus store NMN?

Pacáiste% 3a Úsáid séalaithe export-grade drumaí agus folús-séalaithe scragall pacáistiú % 2c nó pacáiste na earraí de réir do chustaiméirí % 27 riachtanais.

Stóráil: For a short time, you can keep it in a dry and cool place and make it avoid sunlight. For a long time, please keep it under 15 degree below zero.

Más mian leat a a fhios an íon pyrazinamide % 2c tú is féidir teagmháil Xi% 27an Sonwu. Cliceáil an ríomhphost % 2c agus ansin tú get ard-chaighdeán pyrazinamide púdar.

Ríomhphost% 3a sales@sonwu.com

Clibeanna Te: pyrazinamide púdar% 2c tSín% 2c soláthraithe% 2c monaróirí% 2c monarcha% 2c mórdhíola% 2c ceannaigh% 2c praghas% 2c mórchóir 2c pure% 2c amh% 2c soláthar% 2c le haghaidh díol